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Bioengineering
Volume 11
Issue 6
10.3390/bioengineering11060603
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Open AccessArticle
by Wolfgang Anton Goetz Wolfgang Anton Goetz SciProfiles Scilit Preprints.org Google Scholar Jiang Yao Jiang Yao SciProfiles Scilit Preprints.org Google Scholar Michael Brener Michael Brener SciProfiles Scilit Preprints.org Google Scholar Rishi Puri Rishi Puri SciProfiles Scilit Preprints.org Google Scholar Martin Swaans Martin Swaans SciProfiles Scilit Preprints.org Google Scholar Simon Schopka Simon Schopka SciProfiles Scilit Preprints.org Google Scholar Sigrid Wiesner Sigrid Wiesner SciProfiles Scilit Preprints.org Google Scholar Marcus Creutzenberg Marcus Creutzenberg SciProfiles Scilit Preprints.org Google Scholar Horst Sievert Horst Sievert SciProfiles Scilit Preprints.org Google Scholar Horst Sievert is the Director of the CardioVascular Center Frankfurt and of the Department of and of[...] Read more Ghassan S. Kassab Ghassan S. Kassab SciProfiles Scilit Preprints.org Google Scholar
1
Cardiothoracic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany
2
Dassault Systèmes, Johnston, RI 02919, USA
3
Division of Cardiology, Columbia University Irving Medical Center, New York, NY 10027, USA
4
Cleveland Clinic, Cleveland, OH 44195, USA
5
St. Antonius Ziekenhuis, 3435 Nieuwegein, The Netherlands
6
CardioVascular Center, 60389 Frankfurt, Germany
7
California Medical Innovations Institute, San Diego, CA 92121, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Bioengineering 2024, 11(6), 603; https://doi.org/10.3390/bioengineering11060603
Submission received: 12 April 2024 / Revised: 4 June 2024 / Accepted: 10 June 2024 / Published: 12 June 2024
(This article belongs to the Special Issue Computational Models in Cardiovascular System)
Abstract
During systole, longitudinal shortening of the left ventricle (LV) displaces the aortic root toward the apex of the heart and stretches the ascending aorta (AA). An in silico study (Living Left Heart Human Model, Dassault Systèmes Simulia Corporation) demonstrated that stiffening of the AA affects myocardial stress and LV strain patterns. With AA stiffening, myofiber stress increased overall in the LV, with particularly high-stress areas at the septum. The most pronounced reduction in strain was noted along the septal longitudinal region. The pressure–volume loops showed that AA stiffening caused a deterioration in LV function, with increased end-systolic volume, reduced systolic LV pressure, decreased stroke volume and effective stroke work, but elevated end-diastolic pressure. An increase in myofiber contractility indicated that stroke volume and effective stroke work could be recovered, with an increase in LV end-systolic pressure and a decrease in end-diastolic pressure. Longitudinal and radial strains remained reduced, but circumferential strains increased over baseline, compensating for lost longitudinal LV function. Myofiber stress increased overall, with the most dramatic increase in the septal region and the LV apex. We demonstrate a direct mechanical pathophysiologic link between stiff AA and reduced longitudinal left ventricular strain which are common in patients with HFpEF.
Keywords: in silico; finite element method; computational simulation; aortic stiffness; atrioventricular plane displacement; ventricular strain; ventricular function; HFpEF
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MDPI and ACS Style
Goetz, W.A.; Yao, J.; Brener, M.; Puri, R.; Swaans, M.; Schopka, S.; Wiesner, S.; Creutzenberg, M.; Sievert, H.; Kassab, G.S. The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model. Bioengineering 2024, 11, 603. https://doi.org/10.3390/bioengineering11060603
AMA Style
Goetz WA, Yao J, Brener M, Puri R, Swaans M, Schopka S, Wiesner S, Creutzenberg M, Sievert H, Kassab GS. The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model. Bioengineering. 2024; 11(6):603. https://doi.org/10.3390/bioengineering11060603
Chicago/Turabian Style
Goetz, Wolfgang Anton, Jiang Yao, Michael Brener, Rishi Puri, Martin Swaans, Simon Schopka, Sigrid Wiesner, Marcus Creutzenberg, Horst Sievert, and Ghassan S. Kassab. 2024. "The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model" Bioengineering 11, no. 6: 603. https://doi.org/10.3390/bioengineering11060603
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
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MDPI and ACS Style
Goetz, W.A.; Yao, J.; Brener, M.; Puri, R.; Swaans, M.; Schopka, S.; Wiesner, S.; Creutzenberg, M.; Sievert, H.; Kassab, G.S. The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model. Bioengineering 2024, 11, 603. https://doi.org/10.3390/bioengineering11060603
AMA Style
Goetz WA, Yao J, Brener M, Puri R, Swaans M, Schopka S, Wiesner S, Creutzenberg M, Sievert H, Kassab GS. The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model. Bioengineering. 2024; 11(6):603. https://doi.org/10.3390/bioengineering11060603
Chicago/Turabian Style
Goetz, Wolfgang Anton, Jiang Yao, Michael Brener, Rishi Puri, Martin Swaans, Simon Schopka, Sigrid Wiesner, Marcus Creutzenberg, Horst Sievert, and Ghassan S. Kassab. 2024. "The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model" Bioengineering 11, no. 6: 603. https://doi.org/10.3390/bioengineering11060603
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
Bioengineering, EISSN 2306-5354, Published by MDPI
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